Medicare Part B Covered ($0 Copay)PANEL-PID-24

Primary Immunodeficiency & Autoimmune Health

Primary Immunodeficiency Disorders (PIDDs) frequently go undiagnosed in adults, masquerading as routine recurrent sinus, ear, or bronchial infections. This panel sequences genes governing antibody synthesis, T-cell regulation, and complement pathways, providing physicians with definitive answers to resolve lifelong immune vulnerabilities.

Immune Genes24 Targets

Collection Time5 Minutes

Medicare Out-of-Pocket$0.00

Lab CertificationCLIA & CAP

Check If You Qualify

Takes under 2 minutes • 100% Covered under Medicare Part B

Verify $0 Eligibility →

HIPAA 256-Bit Encrypted

Who Should Consider This Screening?

Healthcare providers recommend this diagnostic panel for individuals with the following personal or family health indicators:

Four or more new ear infections within one year, or two or more serious sinus infections within one year.

Two or more episodes of pneumonia within a three-year period.

Need for intravenous antibiotics to clear recurring bacterial infections.

Persistent unexplained low white blood cell or immunoglobulin levels.

Co-occurrence of multiple autoimmune conditions (e.g., lupus, rheumatoid arthritis, thyroiditis).

Biomarkers & Genes Evaluated in this Panel

Processed using high-complexity Next-Generation Sequencing (NGS) in CLIA-certified and CAP-accredited partner laboratories.

Gene Symbol / Name	Clinical Significance	Actionable Impact
BTKBruton Tyrosine Kinase	Essential for B-cell maturation and immunoglobulin synthesis.	Enables targeted immunoglobulin replacement therapy (IVIG/SCIG) to halt recurring bacterial infections.
STAT1 & STAT3Signal Transducer and Activator of Transcription	Regulates interferon responses and mucosal barrier immunity against fungal and viral pathogens.	Guides precise antimicrobial prophylaxis and biological immunomodulatory therapies.
NFKB1 & CTLA4Immune Checkpoint and Nuclear Factor Regulators	Governs immune tolerance and limits systemic autoimmune hyperactivation.	Informs therapeutic decisions for combined immunodeficiency with autoimmune enteropathy or cytopenias.

Sample Report & Diagnostic Action Plan

Every patient receives an easy-to-understand diagnostic summary and a detailed clinical report tailored for their primary care doctor.

Sample Result ClassificationPathogenic Variant Identified

Identified Finding:

Variant of Clinical Significance identified in NFKB1 (p.Arg157Ter).

Clinician Recommendation:

Recommend quantitative immunoglobulin profiling (IgG, IgA, IgM), clinical immunologist referral, and evaluation for prophylactic antibiotic protocols.

Medicare Part B Coverage Guidelines

Understand how federal CMS medical necessity guidelines apply to this specific diagnostic screening:

Covered 100% When Medically Necessary

Medicare Part B covers immunodeficiency genomic evaluations when ordered by a physician for patients presenting with recurrent severe infections or documented immune dysfunction.

Our network of state-licensed physicians reviews your medical profile to confirm eligibility before any kit is mailed.

$0 Out-of-Pocket for Qualifying Seniors

Ready to Check Your Eligibility for Primary Immunodeficiency & Autoimmune Health?

Takes under 2 minutes • Painless at-home cheek swab • 100% Physician Reviewed

Start 2-Minute Pre-Qualification →